cancer cell — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T22336	Galloflavin		Dehydrogenase
	Galloflavin inhibits both the A and B isoforms of lactate dehydrogenase with Ki of 5.46 µM and 15.06 µM, respectively. Galloflavin is also a potential anticancer agent.		Dehydrogenase
T9929	Ramucirumab		VEGFR
	Ramucirumab is a human VEGFR-2 antagonist for the treatment of solid tumors.		VEGFR
T21588	Olomoucine		ERK , CDK
	Olomoucine is an ATP competitive inhibitor of Cdk2/cyclin A, Cdc2/CyclinB, CDK2/CyclinE, CDK5/p35, and ERK1/p44 MAP kinase with IC50s of 7, 7, 7, 3 and 25 µM, respectively. Olomoucine regulates cell cycle and exhibits an...		ERK , CDK
T2455	PFK-015	PFK15,PFK 015	Glucokinase , Autophagy
	PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).		Glucokinase , Autophagy
T9810	TNIK-IN-5		Wnt/beta-catenin
	TNIK-IN-5 is an potent TNIK inhibitor (IC50= 0.05 μM). TNIK-IN-5 potently inhibits Wnt signaling in intact cells. TNIK-IN-5 exhibits excellent in vitro anti-colorectal cancer activity.		Wnt/beta-catenin
T10777	CG347B		HDAC
	CG347B is a selective inhibitor of HDAC6.		HDAC
T13818	Phytohemagglutinin	PHA-M	Apoptosis
	Phytohemagglutinin (PHA-M) is a lectin, isolated from the red kidney bean , induces apoptosis via increasing proapoptotic protein Bax and activating caspases-3. Anti-tumor activity		Apoptosis
T6812L	Cyclo(-RGDfK) TFA		Integrin
	Cyclo(-RGDfK) is a selective αvβ3 integrin inhibitor(IC50 : 0.94 nM).		Integrin
T2325	Neratinib	HKI-272	EGFR , HER
	Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.		EGFR , HER
T9271	RAD51-IN-1		DNA/RNA Synthesis
	Rad51-in-1 is a derivative of B02 and an effective inhibitor of Rad51.		DNA/RNA Synthesis
TN1153	Polyporenic acid C		Apoptosis , PARP , Caspase , PI3K
	Polyporenic acid C shows inhibitory activity against human collagenase.		Apoptosis , PARP , Caspase , PI3K
TN1839	Kumatakenin	Jaranol,Kaempferol 3,7-O-dimethyl ether	Apoptosis , Anti-infection
	Kumatakenin can suppress >80% of the SOS-inducing activity of Trp-P-1 at <0.06 micromol/mL.		Apoptosis , Anti-infection
T8668	HM03		HSP
	HM03 is a potent and selective inhibitor of HSPA5, and has anticancer activity.		HSP
T7200	TAK-960		PLK
	TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively.		PLK
T5808	(-)-Oxypeucedanin hydrate	OXYPEUCEDANIN HYDRATE	Others
	(-)-Oxypeucedanin hydrate is a furanocoumarin. It has a role as a metabolite.		Others
T6812	Cyclo(-RGDfK)	Cyclo (-RGDfK)	Integrin
	Cyclo(-RGDfK) (Cyclo (-RGDfK)) is an effective and specific αvβ3 integrin inhibitor.		Integrin
T11631	IFSP1		Ferroptosis
	iFSP1, a potent, selective, and glutathione-independent ferroptosis suppressor protein 1 (FSP1) (AIFM2) inhibitor with an EC50 of 103 nM, sensitizes diverse human cancer cell lines to ferroptosis inducers like (1S,3R)-RS...		Ferroptosis
T22260	Aminopurvalanol A		CDK
	Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1, Cyclin E/cdk2, and P35/cdk5 with IC50 of 33 nM, 33 nM, 28 n...		CDK
T24557	NSC756093	NSC-756093,NSC 756093	Others
	NSC756093 potentially inhibits GBP1:PIM1 interaction. NSC756093 can be used in ovarian cancer studies.		Others
T9014	SKI-178		Apoptosis , S1P Receptor
	SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during ...		Apoptosis , S1P Receptor